25 Aug, 2019
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RESEARCH

 

1. Chemistry of metal complexes

Head: prof. dr. Emira Kahrović

Current research:

1. Synthesis and characterization of new ruthenium complexes

2. Interaction of metal complexes with biomolecules such as DNA and proteins

3. In vitro and in vivo biological activity of the ruthenium complex

4. Synthesis of the complexes with biomimetic activity

Ruthenium complexes have been shown to be compounds with good biological, thermal, electrical and catalytic properties that favor the examination of their chemistry. Today, chemistry of ruthenium complexes develops in two main directions. The first is the design and development of new broad-spectrum metallopharmaceuticals, while the second is the synthesis and application of highly efficient and selective catalysts.

Nucleic acids along with proteins are still considered the main targets of potentially biologically active substances. Therefore, investigation of the interaction of complexes with DNA is usually the first step in biological evaluation.

The development of the novel metal complexes with innovative structures and reactivity in different biological environments attracts huge attention, primarily due to an important role that metals play in various biochemical processes. The molecular design of many novel small inorganic metal complexes is, therefore, inspired by the structural features of the metalloenzyme active sites. These complexes are recognized as biomimetic, and are developed with an ultimate goal to translate structural resemblances with biological originals to the functional ones.

2. Chemical sensors and biosensors

Head: Prof. dr. Emir Turkušić

Current research:

1. Development of new (bio)sensors with electron-transfer mediators based on ruthenium complexes

The development of electrochemical sensors is one of the most propulsive areas of analytical chemistry since the sensors move the detection limits and allow the determination of the desired analyte in complex matrices. Of particular importance is the analytical determination of compounds that are part of the pharmaceutical compositions or represent biomolecules of interest in other fields of research, such as neurotransmitters, amino acids, nucleic acids etc. An effective electron transfer mediator is crucial for the development of new electrochemical sensors. Good electron transfer mediators include oxides of some metals that can occur in multiple oxidation states. In recent years a significant number of electrochemical sensors have been developed with metal complexes as mediators.

Research Team

Dr. sc. Emira Kahrović, full professor

Dr. sc. Emir Turkušićfull professor

Dr. sc. Adnan Zahirović, Senior Assistant

MSc Irnesa OsmankovićSenior Assistant

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ACTIVITIES

 

Current scientific research projects

Emira Kahrović, Adnan Zahirović, Irnesa Osmanković, „New antiproliferative ruthenium complexes: Synthesis and SAR study", Federal Ministry of Education and Science, 2018.

Emir Turkušić, Adnan Zahirović, Irnesa Osmanković, „Development of Ruthenium Complexes as  Mediators for New Sensors", Federal Ministry of Education and Science, 2017.

Emira Kahrović, Emir Turkušić, Framework: Explicit Control Over Spin-states in Technology and Biochemistry, European Cooperation in Science and Technology, 2014.

Some completed scientific research projects

Emira Kahrović, Emir Turkušić, Adnan Zahirović, Irnesa Osmanković, “Ruthenium – flavonoid Complexes as Potential Drugs: Synthesis and Characterization", Federal Ministry of Education and Science, 2015.

Emira Kahrović, Emir Turkušić, Adnan Zahirović, „Interaction -  Intercalation od DNA (deoxyribonucleic acid) with New Ru(III) Schiff Base Complexes", Federal Ministry of Education and Science, 2013.

 

Recent publications indexed in Web of Science

Zahirović, Adnan, Dijana Žilić, Sandra Kraljević Pavelić, Mirsada Hukić, Senada Muratović, Anja Harej, and Emira Kahrović. "Type of complex–BSA binding forces affected by different coordination modes of alliin in novel water-soluble ruthenium complexes." New Journal of Chemistry (2019).

NJC2019

Muzika, Višnja, Samra Čustović, Selma Aličelebić, Esad Ćosovic, Adnan Zahirović & Emira Kahrović. "Dinuclear ruthenium (II) Schiff base complex: a first in vivo study in Swiss albino miceBratislavske lekarske listy 120(1) (2019): 26-34.

Zahirović Adnan, Osmanković Irnesa, Turkušić Emir and Kahrović Emira. Improved method for spectrophotometric determination of ruthenium using 1,10-phenantroline: Applications for analysis of complex compunds.” Analytical Methods, 10 (2018): 5078-5083.

This paper is part of themed collection: "Analytical Methods Recent HOT articles" which is only top 10% of papers published in Analytical Methods. Featured articles are marked as HOT by the handling editor or as recommended by referees.

AM18

Kahrović, Emira, Adnan Zahirović, Aleksandar Višnjevac, Irnesa Osmanković, Emir Turkušić and Harun Kurtagić. „Chalcone and Flavonol Copper(II) Complexes Containing Schiff Base Co-Ligand: Synthesis, Crystal Structures and Catecholase-like Activity.“ Croatica Chemica Acta, 91(2), (2018): 1-13.

CCA18

Zahirović, Adnan, Emira Kahrović, Marina Cindrić, Sandra Kraljević Pavelić, Mirsada Hukić, Anja Harej, and Emir Turkušić. "Heteroleptic ruthenium bioflavonoid complexes: From synthesis to in vitro biological activity.Journal of Coordination Chemistry 70, no. 24 (2017): 4030-4053. (Author personal copy freely available PDF)

JCC2

Turkušić, Emir, Safeta Redžić, Emira Kahrović, and Adnan Zahirović. "Electrochemical Determination of Adrenaline at Ru (III) Schiff Base Complex Modified Carbon Electrodes." Croatica Chemica Acta 90, no. 2 (2017): 1-8.

Kahrović, Emira, Adnan Zahirović, Šeherzada Kadrić, Emir Turkušić, Irnesa Osmanković, and Hurija Džudžević Čančar. "Structural feature of calf thymus deoxyribonucleic acid–ruthenium (III) interaction in aqueous solution by difference Fourier transformed infrared spectroscopy.Spectroscopy Letters 50, no. 8 (2017): 426-431. (Author personal copy freely available PDF)

Kahrović, Emira, Adnan Zahirović, Sandra Kraljević Pavelić, Emir Turkušić, and Anja Harej. "In vitro anticancer activity of binuclear Ru (II) complexes with Schiff bases derived from 5-substituted salicylaldehyde and 2-aminopyridine with notably low IC50 values.Journal of Coordination Chemistry 70, no. 10 (2017): 1683-1697. (Author personal copy freely available PDF)

Redžić, Safeta, Emira Kahrović, Adnan Zahirović, and Emir Turkušić. "Electrochemical Determination of Dopamine with Ruthenium (III)-Modified Glassy Carbon and Screen-Printed Electrodes.Analytical Letters 50, no. 10 (2017): 1602-1619. (Author personal copy freely available PDF)

Pazalja, Mirha, Emira Kahrović, Adnan Zahirović, and Emir Turkušić. "Electrochemical sensor for determination of L-cysteine based on carbon electrodes modified with Ru (III) Schiff base complex, carbon nanotubes and Nafion.Int. J. Electrochem. Sci 11 (2016): 10939-52.

Kahrović, Emira, Adnan Zahirović, Emir Turkušić, and Sabaheta Bektaš. "A Dinuclear Ruthenium (II) Schiff Base Complex with Dissimilar Coordination: Synthesis, Characterization, and Biological Activity.Zeitschrift für anorganische und allgemeine Chemie 642, no. 6 (2016): 480-485. (Author personal copy freely available PDF)

 

Presentations at international conferences 

Adnan Zahirović, Emir Turkušić, Irnesa Osmanković, Aleksandar Višnjevac and Emira Kahrović, Thermodynamic Aspect of Dicopper(II) Chalcone Complexes Interaction with CT DNA, Pure and Applied Chemistry International Conference 2019, Bangkok, Thailand, February 7 – 8, 2019.

Aleksandar Višnjevac, Adnan Zahirović, Irnesa Osmanković, Emir Turkušić, Emira Kahrović, Crystal structures and bioactivity studies of four novel chalcone and flavonol copper(II) complexes containing Schiff base co-ligand, 31st European Crystallographic Meeting, Oviedo, Spain, August 22 – 27, 2018, Book of Abstracts, MS36-P35: Acta Cryst. (2018). A74, e397. 

Adnan Zahirović, Emira Kahrović, Marina Cindrić, Emir Turkušić, Irnesa Svraka. Synthetic Approaches to First Ruthenium – Quercetin Complexes: Insight into Design, Reactivity towards CT DNA and Antioxidant Activity. 13th European Biological Inorganic Chemistry Conference, Budapest, Hungary, August 28 – September 01 2016, Book of Abstracts, p. 301 (P148).

Hungary1

Emira Kahrović, Adnan Zahirović, Šeherzada Kadrić, Emir Turkušić. Structural View on Ru(III)-CT DNA Interaction in Aqueous Solution by FTIR Spectroscopy. 13th European Biological Inorganic Chemistry Conference, Budapest, Hungary, August 28 – September 01 2016, Book of Abstracts, p. 184 (P031).

Hungary2

Safeta Redžić, Emira Kahrović, Mithat Asotić, Emir Turkušić. New amperometric sensor for dopamine in the presence of ascorbic acid using Sodium bis[N-2-oxyphenyl-5-bromosaliciylideneiminato-ONO]ruthenate(III)/MWNTs/Nafion modified GC electrode. Pure and Applied Chemistry International Conference, Bangkok, Thailand, February 2016, Book of Abstracts.

Adnan Zahirović, Sabaheta Bektaš, Ilda Graca, Maida Puška, Emir Turkušić, Emira Kahrović, A new complex of Ru(III) with N-(2-pyridyl)salicylideneimine: DNA binding properties and activity against Staphylococcus Aureus, 12 th European Biological Inorganic Chemistry Conference, Zurich, Switzerlan, August 24-28, 2014, J. Biol. Inorg. Chem. (2014), 19 (Suppl 2), S790.

Adnan Zahirovic, Sabina Begic-Hairlahovic, Nevzeta Ljubijankic, Emir Turkusic, Emira Kahrovic, The Spectroscopic characterization of some Ru(III) complexes with Schiff bases derived from salicylaldehyde and investigation of interaction with CT DNA, International Turkish Congress on Molecular Spectroscopy, Istanbul, Turkey, September 15-20, 2013, Book of Abstracts, Applied Spectroscopies – P7, p. 88.

Turska

Emira Kahrović, Emir Turkušić, Nevzeta Ljubijankić, Sabina Begić, Vera Dugandžić and Adnan Zahirović “The Spectroscopic Investigations of a Ruthenium Schiff Base Complex with CT DNA”, 40 International Congress on Coordination Chemistry, Valencia, Spain, September 9-13, 2012. Book of Abstracts, MS.D2.P.601, C404-C405.

COLLABORATION

In the research of metal complex compounds, primarily those of ruthenium, and their potential applications in various fields, team members cooperate with several laboratories from Bosnia and Herzegovina, region and Europe.

- Institut Ruđer Bošković, Zagreb, Hrvatska

- Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu, Hrvatska

- Odjel za biotehnologiju, Sveučilište u Rijeci, Hrvatska

- Zavod za biomedicinsku dijagnostiku i ispitivanje Nalaz, Sarajevo

- Medicinski fakultet, Univerzitet u Sarajevu, BiH

- Klinički centar Univerziteta u Sarajevu, Sarajevo, BiH

- Institut za nuklearne nauke Vinča, Beograd, Srbija

- University of Florence, Florence, Italy

- Karl-Franzens University, Graz, Austria

- University of Pardubice, Pardubice, Czech Republic

- University of Avignon, France

- Federalni zavod za poljoprivredu, Sarajevo, BiH

 

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